Aktifitas Stimulan Sistem Saraf Pusat Ekstrak Biji Pinang ( Areca catechu, L ) Terhadap Mencit Putih ( Mus musculus, L)
DOI:
https://doi.org/10.52689/higea.v3i1.46Keywords:
Stimulant activity, central nerve systems, areca seed extractAbstract
The stimulant activity of central nerve systems of areca seed (Areca cathecu, L.), at white mouse ( Mus musculus, L ) had been done by using method hanging test, evasi test, swim test and discrimination maze. Drug dose given is 0.5 mg/20 gram BW white mouse, 1 mg/20 gram BW white mouse, 2 mg/ 20 gram BW white mouse in oral mechanism. As negative control is applied by Tween 80 2% and condensation of comparator is applied by Caffeine.Activity test result from seed extract Pinang ( Areca cathecu, L. ) to white mouse ( Mus musculus, L. ) the obtained result signifikan ( P < 0.01 ) as stimulant central nerve systems.References
Dalimartha,S., 2005, Tanaman Obat di Lingkungan Sekitar, Puspa Swara, Jakarta.
Dewick, P.M., 2000, Medicinal Natural Products, A Biosynthetic Approach second edition, John Weley & Sons, UK.
Depertemen Kesehatan Republik Indonesia, 1985, Tanaman Obat Indonesia jilid II. Direktorat POM Bakti Husada. Jakarta.
Ganong,W.F., 2002, Buku Ajar Fisiologi Kedokteran edisi 20, Penerbit Buku Kedokteran EGC, Jakarta.
Goodmand & Gillman, 1990, The Pharmacologycal Basic of Terapeutics Tenth Edition, Pergamon Press, New York.
Harbone, J.B., 2004. Phytochemical Methods, 2nd edition., Chapman and Hall, New York.
Hariana, A., 2004, Tumbuhan obat & khasiatnya, Seri 1, Penebar Swadaya
Katzung, Bertram G, 2004. Farmakologi Dasar dan Klinik edisi VIII, Penerbit Buku Kedokteran EGC, Jakarta.
Mutschler, A., 1999, Dinamika Obat. Farmakologi dan Toksikologi edisi V. Penerbit ITB, Bandung.
Thorndike, E.L., 1911, Animal Intelligence, Macmillon, New York.
Van der Vossen, HAM & Wessel, M., 2000, Plant Resources of South East Asia no.16 Stimulants. Prosea – Bogor.
