Mikroenkapsulasi Parasetamol Dengan Polimer Hidroxy Prophyl Methyl Celluloce (HPMC) Menggunakan Metoda Penguapan Pelarut
DOI:
https://doi.org/10.52689/higea.v2i2.35Kata Kunci:
Microencapsulation, Paracetamol, HPMCAbstrak
The study on paracetamol microencapsulation by solvent evaporation method using hidroxy prophyl methil celluloce (HPMC) as a polimer has been done. The paracetamol Quantitation by UV spectrofotometer at 243 nm, using phosphate buffer pH 5,8 as the dissolution medium. The result showed that 1st formula's dissolution rate is higher than 2nd and 3nd formulas, because the HPMC content of those formula are higher than the 1st formula, so paracetamol as a core are coored thicker, so that lower in drug rate releasing. The kinetic releasing mechanism of active ingredient from the microcapsule following the zero order, first order and Higuchi equation.Referensi
Ansel, H.C., 1989, Introduction to Pharmaceutical Dosage Form, diterjemahkan oleh F. Ibrahim, Pengantar Bentuk Sediaan Farmasi, edisi IV, Universitas Indonesia, Jakarta.
Benita, S., 1991, Microencapsulation: Methods and Industrial Application, Marcel Dekker Inc. New York.
Departemen Kesehatan Republik Indonesia. 1979. Farmakope Indonesia edisi III, Jakarta
Departemen Kesehatan Republik Indonesia. 1995. Farmakope Indonesia edisi IV, Jakarta
Ganiswarna, G. Sulistia., 1995, Farmakologi dan Terapi, Edisi IV, Universitas Indonesia, Jakarta.
Lachman, L., H. A., Lieberman and J. L. Kanig., 1994, The Theory and Practice of Industrial PHarmachy, 2nd, Judul Terjemahan Teori dan Praktek IndusriFarmasi edisi II dan edisi III, diterjemahkan oleh Siti Suyatmi, Universitas Indonesia, Jakarta.
Mutschler, E., 1991. Dinamika Obat, Edisi V, Diterjemahkan oleh Mathilda Widianto dan Anna Setiadi Ranti, Bandung: Penerbit Institut Teknologi Bandung
Pharmaceutical Press. 2007. Martindale the extra pharmacopeia. (35th ed). London
United State Pharmacopeial Convention Inc. 1995. The United State of pharmacopedia. (30th ed). New York.
Voight, R., 1994, Buku Pelajaran Teknologi Farmasi, Edisi V, diterjemahkan oleh Soendani Noeromo, Gajah Mada University Press, Yogyakarta.
