Pengaruh Pemberian Ekstrak Daun Gaharu (Aquilaria Malaccensis Lam.) Terhadap Aterosklerosis Pada Burung Puyuh Jantan (Coturnix-Coturnix Japonica)
DOI:
https://doi.org/10.52689/higea.v6i2.109Keywords:
leaf extracts agarwood, atherosclerosis, MLT (high fat food) and PTU (propilthiourasil)Abstract
Study about the influence of agarwood leave's extract (Aquilaria malaccensis Lam.) on the formation of atherosclerosis in male quail (coturnic-coturnix japonica) induced high fat feeding and prophylthiourasil. Animal experiments were grouped into 5 consisting of Group I as a negative control only given food strander, group II as a positive control and PTU given MLT groups III, IV, V given leaf extract of aloes with a dose of 100 mg / kg BW, 300 mg / kg BW, 900 mg / kg BW and, along with the MLT and PTU the extract was given orally once a day for 60 day. The doses used were 100, 300, 900 mg/kg body weight respectively. Control groups was given food standar. Result showed that the administration of the agarwood leaf extract could prevent formation of atherosclerosis in male quail significantly (P < 0.05). The optimal effect showed doses 100 mg/kg BW.References
Badan Pengawasa Obat dan Makanan RI. (2004). Monografi Ekstrak Tumbuhan Obat Indonesia. Volume 1. Jakarta:Badan Pemeriksa Obat dan Makanan RI.
Departemen Kesehatan Republik Indonesia. (1985). Cara pembuatan simplisia. Jakarta : Departemen Kesehatan Republik Indonesia.
Departemen Kesehatan Republik Indonesia. (2000). Parameter standar umum ekstrak tumbuhan obat. (Edisi I). Jakarta: Direktorat Jendral Pengawasan Obat dan Makanan, Direktorat Pengawasan Obat Tradisional.
Havsteen B. (1983). Flavanoids, a class of natural products of high pharmacologi-cal potency. Biochem Pharmacol. 32 : 1141-1148.
Jhones, D. S. (2010). Statistik farmasi. Penerjemah: Harrizul Rivai, Jakarta: Penerbit EGC.
Kiernan, J. A. (1990). Farmakologi dan histochemical methods : Theory and Practice. New York: Pergamon press, oxford.
Konishi, T., Konoshima, T., Shimeda, Y & Kiyosawa, S. (2002). Six New 2-(2-Phenyleth-yl) chromones from Agarwood, J. Pharmacognosy resc. 50 (3) : 419-422.
Leeson, C. R., Leeson, T. S., & Paparo, A. A. (1989). Buku ajar histologi. (Edisi V). Penerjemah: Staf ahli Histologi FKUI, Jakarta: Penerbit Buku Kedokteran.
Lemens, R. H. M. J. & Bungapraphatsura, M. (2003). Plant resources of south east asia. Jilid 12. (Edisi 3). Medicinal and Poisonous Plants 3. Leiden : Backuys Publisher.
Price, S.A. & Wilson, N. L. (2006). Patofisiologi konsep klinis proses-proses penyakit. (Edisi 6). Penerjemah: H. Hartanto dkk. Jakarta: Penerbit Buku Kedokteran EGC.
Setyowati, F. M. & Wardah. (2007). Keanekaragaman tumbuhan obat masyarakat talang mamak di sekitar taman nasional bukit tigapuluh, Riau. Biodiversitas. 8 (3) : 228 - 232.
Vogel. (2002). Drug discovery and evaluation pharmacological assays. German. Springer.
Winarsi, H. (2007). Antioksidan alami dan radikal bebas, potensi dan aplikasinya dalam kesehatan.Yogyakarta: PT. Kanisius.
Yoneda, K., Nakanishi, T., Yamagata, E., Nagashima, T., Kawasaki, I., Yoshi-da, T., Mori, H & Miura, I. (1984). Three fragrant sesquiterepenes of Agarwood, Phytochemistry, 23(11) : 2066-2067.
